Key messages

• Trimedazidine is a partial fatty acid oxidation inhibitor
• There are many clinical evidences on the effects of partial fatty acid oxidation inhibitor on LV function
• βblockers are effective in reduce all cause mortality in HF, with some differences between drugs (carvedilol is better than metoprolol in terms of catecholamine spill-over): different drugs have different effects!
• The beneficial effects of βblockers in patients with heart failure may depend by modification of metabolic substrate preference by the myocardium
• Ranolazine, another partial fatty acid oxidation inhibitor, protects from doxorubicin – induced oxidative stress and cardiac dysfunction and signifcantly reduced HbA1c in patients with diabetes and CAD
• SGLT2 offer cardiorenal protection, opening a new way, a new paradigm of treatment.